Human genomics is witnessing an ongoing paradigm shift from a single reference sequence
to a pangenome form, but populations of Asian ancestry are underrepresented. Here we …

Ischemic stroke is a leading cause of global mortality and long-term disability. However,
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …

Human Y-chromosomes are characterized by nonrecombination and uniparental
inheritance, carrying traces of human history evolution and admixture. Large-scale …

We present the largest whole-genome sequencing (WGS) study of non-small cell lung
cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 …

Characterizing natural selection signatures and relationships with phenotype spectra is
important for understanding human evolution and both biological and pathological …

Large-scale genomic projects and ancient DNA innovations have ushered in a new
paradigm for exploring human evolutionary history. However, the genetic legacy of …

Genomic research that targets large-scale, prospective birth cohorts constitutes an essential
strategy for understanding the influence of genetics and environment on human health …

Introduction The health effects of ambient ozone have been investigated in many previous
studies. However, the effects of long-term exposure to ambient ozone on the incidence of …

Structural variants (SVs), accounting for a larger fraction of the genome than SNPs/InDels,
are an important pool of genetic variation, enabling environmental adaptations. Here, we …

Background The underrepresentation of human genomic resources from Southern Chinese
populations limited their health equality in the precision medicine era and complete …