Although sequencing-based high-throughput chromatin interaction data are widely used to
uncover genome-wide three-dimensional chromatin architecture, their sparseness and high …

Motivation The spatial genome organization of a eukaryotic cell is important for its function.
The development of single-cell technologies for probing the 3D genome conformation …

The functional performance of immune cells relies on a complex transcriptional regulatory
network. The three-dimensional structure of chromatin can affect chromatin status and gene …

Motivation Hi-C technology has been the most widely used chromosome conformation
capture (3C) experiment that measures the frequency of all paired interactions in the entire …

The genome-wide single-cell chromosome conformation capture technique, ie single-cell Hi-
C (ScHi-C), was recently developed to interrogate the conformation of the genome of …

Abstract Motivation High-resolution Hi-C contact matrices reveal the detailed three-
dimensional architecture of the genome, but high-coverage experimental Hi-C data are …

Computational enhancement is an important strategy for inferring high-resolution features
from genome-wide chromosome conformation capture (Hi-C) data, which typically have …

Hi-C is a chromosome conformation capture assay used to study 3D genome organization.
The recent development of single-cell Hi-C technologies has further enabled the …

The spatial organization of chromatin is fundamental to gene regulation and essential for
proper cellular function. The Hi-C technique remains the leading method for unraveling 3D …

The spatial arrangement revealed by chromatin interactions in Hi-C data is inherently
dependent on its resolution. Obtaining high-resolution Hi-C sequencing data remains a …