More than 3000 type II restriction endonucleases have been discovered. They recognize
short, usually palindromic, sequences of 4–8 bp and, in the presence of Mg2+, cleave the …

Homing endonucleases confer mobility to their host intervening sequence, either an intron
or intein, by catalyzing a highly specific double-strand break in a cognate allele lacking the …

The heterotrimeric influenza virus polymerase, containing the PA, PB1 and PB2 proteins,
catalyses viral RNA replication and transcription in the nucleus of infected cells. PB1 holds …

Restriction–modification (RM) systems are composed of genes that encode a restriction
enzyme and a modification methylase. RM systems sometimes behave as discrete units of …

This article continues the series of Surveys and Summaries on restriction endonucleases
(REases) begun this year in Nucleic Acids Research. Here we discuss 'Type II'REases, the …

DNA hydrolysis mediated by di-and multi-nuclear metal complexes is of increasing
importance in biotechnology and medicine. Many systems for enzyme-mediated nucleic acid …

Proteins display the capacity for adaptation to new functions, a property critical for
evolvability. But what structural principles underlie the capacity for adaptation? Here, we …

Holliday junction resolvases (HJRs) are key enzymes of DNA recombination. A detailed
computer analysis of the structural and evolutionary relationships of HJRs and related …

Proteins belonging to PD-(D/E) XK phosphodiesterases constitute a functionally diverse
superfamily with representatives involved in replication, restriction, DNA repair and tRNA …

Tonicity-responsive enhancer binding protein (TonEBP), also known as NFAT5, is a unique
member of the NFAT family of transcription factors that regulates gene expression induced …