Mitochondria are the cytoplasmic organelles mostly known as the “electric engine” of the
cells; however, they also play pivotal roles in different biological processes, such as cell …

Metformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin inhibits
hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent …

Simple Summary Failure of chemotherapy is common during the treatment of colon cancer,
and there is a compelling need to develop alternative therapeutic approaches against this …

Sirtuins (SIRTs) are a family of class III histone deacetylases (HDACs) consisting of seven
members, widely expressed in mammals. SIRTs mainly participate in metabolic …

Abstract Prospero-related homeobox 1 (PROX1) is a homeobox transcription factor known to
promote malignant transformation and stemness in human colorectal cancer (CRC) …

Simple Summary Colorectal cancer (CRC) is the second leading cause of cancer-related
deaths and the most frequently diagnosed cancer type. CRC risk can be preventable by …

Metformin has been known to treat type 2 diabetes for decades and is widely prescribed
antidiabetic drug. Recently, its anticancer potential has also been discovered. Moreover …

This study investigated the chemotherapeutic effects of 5‐fluorouracil (5‐FU), metformin
(Met), and/or thymoquinone (TQ) single/dual/triple therapies in the HT29, SW480 and …

Background Sodium-glucose transporter 2 (SGLT2) inhibitors (iSGLT2) are approved
medications for type 2 diabetes. Recent studies indicate that iSGLT2 inhibit the growth of …

Abstract “Exterior-interior correlation between the lung and large intestine” is one of the
important contents of traditional Chinese medicine. This theory describes the role of the lung …