The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …

The tumor suppressor p53 maintains an equilibrium between self-renewal and
differentiation to sustain a limited repertoire of stem cells for proper development and …

Many cancers express mutant p53 proteins that have lost wild-type tumor suppressor activity
and, in many cases, have acquired oncogenic functions that can contribute to tumor …

The p53 gene family members p53, p73, and p63 display several isoforms derived from the
presence of internal promoters and alternative splicing events. They are structural homologs …

The tumor suppression activity of p53 is frequently impaired in cancers even when a wild-
type copy of the gene is still present, suggesting that a dominant-negative effect is exerted …

The interaction of Human Serum Albumin (HSA) with the microRNA, miR4749, was
investigated by Atomic Force Spectrscopy (AFS), static and time-resolved fluorescence …

Surface Plasmon Resonance (SPR) is a powerful technique to study the kinetics of
biomolecules undergoing biorecognition processes, particularly suited for protein-protein …

Simple Summary The tumor suppressor gene TP53 is found mutated in around half of
human cancers. The accumulation of the mutant p53 protein in the form of aggregates in …

Background Mutations within the DNA binding domain (DBD) of the tumor suppressor p53
are found in> 50% of human cancers and may significantly modify p53 secondary structure …

Abstract β 2-Microglobulin (B2M) is a human protein involved in the regulation of immune
response and represents a useful biomarker for several diseases. Recently, anti-B2M …