Epilepsy encompasses a group of heterogeneous brain diseases that affect more than 50
million people worldwide. Epilepsy may have discernible structural, infectious, metabolic …

Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …

Elevated impulsivity is a key component of attention-deficit hyperactivity disorder (ADHD),
bipolar disorder and juvenile myoclonic epilepsy (JME). We performed a genome-wide …

Juvenile myoclonic epilepsy (JME), a lifelong disorder that starts during adolescence, is the
most common of genetic generalized epilepsy syndromes. JME is characterized by …

Primary cilia are evolutionarily conserved microtubule-based organelles that protrude from
the surface of almost all cell types and decode a variety of extracellular stimuli. Ciliary …

ICK (also known as CILK1) is a mitogen-activated protein kinase–like kinase localized at the
ciliary tip. Its deficiency is known to result in the elongation of cilia and causes ciliopathies in …

Ciliogenesis associated kinase 1 (CILK1) was previously known as intestinal cell kinase
because it was cloned from that origin. However, CILK1 is now recognized as a widely …

The primary cilium functions as a cellular sensory organelle and signaling antenna that
detects and transduces extracellular signals. Mutations in the human gene CILK1 …

In humans, ciliary dysfunction causes ciliopathies, which present as multiple organ defects,
including developmental and sensory abnormalities. Sdccag8 is a centrosomal/basal body …

Epilepsy is a neurological network disease with genetics playing a much greater role than
was previously appreciated. Unfortunately, the relationship between genetic basis and …