Unravelling exemestane: From biology to clinical prospects
AF Sobral, C Amaral, G Correia-da-Silva… - The Journal of Steroid …, 2016 - Elsevier
Aromatase inhibitors (AIs) are anti-tumor agents used in clinic to treat hormone-dependent
breast cancer. AIs block estrogens biosynthesis by inhibiting the enzyme aromatase …
breast cancer. AIs block estrogens biosynthesis by inhibiting the enzyme aromatase …
Interest of HRMS systems in analytical toxicology: focus on doping products
N Arbouche, C Bottinelli, E Gerace… - Toxicologie Analytique et …, 2022 - Elsevier
Performance and image enhancing drugs are misused by top athletes, young people and
amateurs like bodybuilders. Their misuses lead to adverse analytical findings in sport but …
amateurs like bodybuilders. Their misuses lead to adverse analytical findings in sport but …
Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line
CL Varela, C Amaral, ET da Silva, A Lopes… - European journal of …, 2014 - Elsevier
Exemestane is a third-generation steroidal aromatase inhibitor that has been used in clinic
for hormone-dependent breast cancer treatment in post-menopausal women. It is known that …
for hormone-dependent breast cancer treatment in post-menopausal women. It is known that …
Detection of designer steroid methylstenbolone in “nutritional supplement” using gas chromatography and tandem mass spectrometry: elucidation of its urinary …
G de Albuquerque Cavalcanti, FD Leal, BC Garrido… - Steroids, 2013 - Elsevier
The use of “nutritional supplements” containing unapproved substances has become a
regular practice in amateur and professional athletes. This represents a dangerous habit for …
regular practice in amateur and professional athletes. This represents a dangerous habit for …
Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with …
C Amaral, A Lopes, CL Varela, ET da Silva… - The international journal …, 2015 - Elsevier
Abstract Around 60–80% of all breast tumors are estrogen receptor-positive. One of the
several therapeutic approaches used for this type of cancers is the use of aromatase …
several therapeutic approaches used for this type of cancers is the use of aromatase …
Validation of a rapid and sensitive LC-MS/MS method for determination of exemestane and its metabolites, 17β-hydroxyexemestane and 17β-hydroxyexemestane-17 …
A novel, rapid and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS)
method was developed and validated for the evaluation of exemestane pharmacokinetics …
method was developed and validated for the evaluation of exemestane pharmacokinetics …
Exemestane potency is unchanged by common nonsynonymous polymorphisms in CYP 19A1: results of a novel anti‐aromatase activity assay examining exemestane …
Exemestane (EXE) treats estrogen receptor positive (ER+) breast cancer in postmenopausal
women by inhibiting the estrogen‐synthesizing cytochrome P450 CYP 19A1. Variability in …
women by inhibiting the estrogen‐synthesizing cytochrome P450 CYP 19A1. Variability in …
Detection of new exemestane metabolites by liquid chromatography interfaced to electrospray-tandem mass spectrometry
G de Albuquerque Cavalcanti, BC Garrido… - The Journal of steroid …, 2011 - Elsevier
Exemestane is an irreversible aromatase inhibitor used for anticancer therapy.
Unfortunately, this drug is also misused in sports to avoid some adverse effects caused by …
Unfortunately, this drug is also misused in sports to avoid some adverse effects caused by …
[PDF][PDF] A novel validated stability-indicating RP-HPLC method for the determination of exemestane (steroidal aromatase inhibitor)
MA Mukthinuthalapati… - Journal of Bioequivalence …, 2015 - researchgate.net
Background: Exemestane is an active irreversible lipophilic steroidal aromatase inhibitor
used to treat breast cancer in addition to surgery and/or radiation in post-menopausal …
used to treat breast cancer in addition to surgery and/or radiation in post-menopausal …
Use of the hyphenated LC-MS/MS technique and NMR/IR spectroscopy for the identification of exemestane stress degradation products during the drug development
EU Stolarczyk, A Rosa, M Kubiszewski… - European Journal of …, 2017 - Elsevier
Abstract Exemestane (6-Methyleneandrosta-1, 4-diene-3, 17-dione) active pharmaceutical
ingredient (EE-3) was subjected to thermal, photolytic, oxidative, acidic and base stress …
ingredient (EE-3) was subjected to thermal, photolytic, oxidative, acidic and base stress …