Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

The tumor microenvironment (TME) harbors a hidden universe of interactions that
profoundly shape the behavior of head and neck cancers (HNCs). HNCs are not merely …

Notch has been implicated in human cancers and is a putative therapeutic target. However,
the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore …

Small cell lung cancer (SCLC) is a recalcitrant, aggressive neuroendocrine-type cancer for
which little change to first-line standard-of-care treatment has occurred within the last few …

Signal transduction pathways often involve transcription factors that promote activation of
defined target gene sets. The transcription factor RBPJ is the central player in Notch …

Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets
account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms …

In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative
pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells …

Notch receptors participate in a conserved pathway in which ligands expressed on
neighboring cells trigger a series of proteolytic cleavages that allow the intracellular portion …

The discovery that Notch activation involves a proteolytic cleavage to release the
intracellular domain (NICD) revolutionized the field of Notch signaling. It resulted in a simple …

Dysregulation of the Notch–RBPJ (recombination signal-binding protein of immunoglobulin
kappa J region) signaling pathway has been found associated with various human diseases …