The merging of click chemistry with discrete photochemical processes has led to the creation
of a new class of click reactions, collectively known as photoclick chemistry. These light …

Advances in bioconjugation and native protein modification are appearing at a blistering
pace, making it increasingly time consuming for practitioners to identify the best chemical …

At its basic conceptualization, photoclick chemistry embodies a collection of click reactions
that are performed via the application of light. The emergence of this concept has had …

In the last decade, visible‐light photoredox catalysis has emerged as a powerful strategy to
enable novel transformations in organic synthesis. Owing to mild reaction conditions (ie …

Bioconjugation chemistry has emerged as a powerful tool for the modification of diverse
biomolecules under mild conditions. Tetrazole, initially proposed as a bioorthogonal …

The bioorthogonality of tetrazole photoclick chemistry has been reassessed. Upon
photolysis of a tetrazole, the highly reactive nitrile imine formed undergoes rapid …

Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …

Ethynylation of various tryptophan‐containing peptides and a single model protein was
achieved using Waser's reagent, 1‐[(triisopropylsilyl) ethynyl]‐1, 2‐benziodoxol‐3 (1 H)‐one …

The genetically encoded non-selective photo-crosslinkers suffer from unpredictable
crosslinking sites and false positive interacting proteins, thus, the identification of protein …

The photo-induced reactions of diaryltetrazoles with carboxylic acids in aqueous solution
were investigated. Besides measuring the apparent second-order rate constant and …