Tumor-induced osteomalacia: a comprehensive review

S Minisola, S Fukumoto, W Xia, A Corsi… - Endocrine …, 2023 - academic.oup.com
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to
overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient …

Regulation and function of the FGF23/klotho endocrine pathways

A Martin, V David, LD Quarles - Physiological reviews, 2012 - journals.physiology.org
Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

[HTML][HTML] Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

JL Babitt, MF Eisenga, VH Haase, AV Kshirsagar… - Kidney international, 2021 - Elsevier
In chronic kidney disease, anemia and disordered iron homeostasis are prevalent and
associated with significant adverse consequences. In 2012, Kidney Disease: Improving …

[HTML][HTML] Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production

V David, A Martin, T Isakova, C Spaulding, L Qi… - Kidney international, 2016 - Elsevier
Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic
kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether …

Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women

M Wolf, TA Koch, DB Bregman - Journal of Bone and Mineral …, 2013 - academic.oup.com
ABSTRACT Fibroblast growth factor 23 (FGF23) is an osteocyte‐derived hormone that
regulates phosphate and vitamin D homeostasis. Through unknown mechanisms, certain …

Tumor-induced osteomalacia: a systematic clinical review of 895 cases

A Bosman, A Palermo, J Vanderhulst… - Calcified tissue …, 2022 - Springer
Tumor-induced osteomalacia (TIO) is a rare and largely underdiagnosed paraneoplastic
condition. Previous reviews often reported incomplete data on clinical aspects, diagnosis or …

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

EG Farrow, X Yu, LJ Summers… - Proceedings of the …, 2011 - National Acad Sciences
Autosomal dominant hypophosphatemic rickets (ADHR) is unique among the disorders
involving Fibroblast growth factor 23 (FGF23) because individuals with R176Q/W and …

Hypophosphataemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside—a systematic review and meta‐analysis

B Schaefer, M Tobiasch, A Viveiros… - British Journal of …, 2021 - Wiley Online Library
Aims Hypophosphataemia is an increasingly recognized side‐effect of ferric carboxymaltose
(FCM) and possibly iron isomaltoside/ferric derisomaltose (IIM), which are used to treat iron …

Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans

EA Imel, M Peacock, AK Gray… - The Journal of …, 2011 - academic.oup.com
Context: In autosomal dominant hypophosphatemic rickets (ADHR), fibroblast growth factor
23 (FGF23) resists cleavage, causing increased plasma FGF23 levels. The clinical …

Tumor‐induced osteomalacia: an important cause of adult‐onset hypophosphatemic osteomalacia in China: report of 39 cases and review of the literature

Y Jiang, W Xia, X Xing, BC Silva, M Li… - Journal of Bone and …, 2012 - academic.oup.com
Tumor‐induced osteomalacia (TIO) is an acquired form of hypophosphatemia. Tumor
resection leads to cure. We investigated the clinical characteristics of TIO, diagnostic …