Gametogenesis is vulnerable to selfish genetic elements that bias their transmission to the
next generation by cheating meiosis. These so-called meiotic drivers are widespread in …

Highlights•Meiotic drive genes are frequently composed of gene families.•Transposable
elements can drive meiotic gene family expansion.•Meiotic drive genes rapidly diversify and …

PIWI-interacting RNA (piRNA) pathways control transposable elements (TEs) and
endogenous genes, playing important roles in animal gamete formation. However, the …

Meiotic drivers are a class of selfish genetic elements whose existence is frequently hidden
due to concomitant suppressor systems. Accordingly, we know little of their evolutionary …

Small noncoding piRNAs act as sequence-specific guides to repress complementary targets
in Metazoa. Prior studies in Drosophila ovaries have demonstrated the function of the piRNA …

Meiotic drive loci distort the normally equal segregation of alleles, which benefits their own
transmission even in the face of severe fitness costs to their host organism. However …

Intragenomic conflicts are fueled by rapidly evolving selfish genetic elements, which induce
selective pressures to innovate opposing repressive mechanisms. This is patently manifest …

Mirtrons are microRNA (miRNA) substrates that utilize the splicing machinery to bypass the
necessity of Drosha cleavage for their biogenesis. Expanding our recent efforts for …

Relatively little is known about the in vivo functions of newly emerging genes, especially in
metazoans. Although prior RNAi studies reported prevalent lethality among young gene …

Y chromosomes are typically viewed as genetic wastelands with few intact genes. Recent
genomic analyses in Drosophila, however, show that gene gain is prominent on young Y …