Update on the effects of microgravity on the musculoskeletal system

OJ Juhl IV, EG Buettmann, MA Friedman… - npj …, 2021 - nature.com
With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

BMP signaling in telencephalic neural cell specification and maturation

B Gámez, E Rodriguez-Carballo… - Frontiers in cellular …, 2013 - frontiersin.org
Bone morphogenetic proteins (BMPs) make up a family of morphogens that are critical for
patterning, development, and function of the central and peripheral nervous system. Their …

Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation

J Gu, Y Lu, F Li, L Qiao, Q Wang, N Li, JA Borgia… - Cell death & …, 2014 - nature.com
The majority of human skeleton develops through the endochondral pathway, in which
cartilage-forming chondrocytes proliferate and enlarge into hypertrophic chondrocytes that …

BMP-induced non-canonical signaling is upregulated during autophagy-mediated regeneration in inflamed mesothelial cells

V Zsiros, N Dóczi, G Petővári, A Pop, Z Erdei… - Scientific Reports, 2023 - nature.com
Previously, we showed that after Freund's adjuvant-induced peritonitis, rat mesothelial cells
regain their epithelial phenotype through mesenchymal-epithelial transition (MET) …

MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability

B Gámez, E Rodríguez-Carballo, R Bartrons… - Journal of Biological …, 2013 - ASBMB
Osteogenesis depends on a coordinated network of signals and transcription factors such as
Runx2 and Osterix. Recent evidence indicates that microRNAs (miRNAs) act as important …

Interplay between BMPs and reactive oxygen species in cell signaling and pathology

C Sánchez-de-Diego, JA Valer, C Pimenta-Lopes… - Biomolecules, 2019 - mdpi.com
The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell
physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that …

Mapping the structure and biological functions within mesenchymal bodies using microfluidics

S Sart, RFX Tomasi, A Barizien, G Amselem… - Science …, 2020 - science.org
Organoids that recapitulate the functional hallmarks of anatomic structures comprise cell
populations able to self-organize cohesively in 3D. However, the rules underlying organoid …

Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins

N McCormack, S O'Dea - Cellular signalling, 2013 - Elsevier
Epithelial to mesenchymal transition (EMT) is a process in which fully differentiated epithelial
cells lose many of their epithelial characteristics and adopt features typical of mesenchymal …

MicroRNAs and post-transcriptional regulation of skeletal development

B Gámez, E Rodriguez-Carballo… - Journal of molecular …, 2014 - jme.bioscientifica.com
MicroRNAs (miRNAs) have become integral nodes of post-transcriptional control of genes
that confer cellular identity and regulate differentiation. Cell-specific signaling and …

Optogenetic control of the BMP signaling pathway

PA Humphreys, S Woods, CA Smith, N Bates… - ACS Synthetic …, 2020 - ACS Publications
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor β
(TGFβ) superfamily and have crucial roles during development; including mesodermal …