The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

The spindle checkpoint ensures proper chromosome segregation during cell division.
Unravelling checkpoint signalling has been a long-standing challenge owing to the …

Open (O) and closed (C) topologies of HORMA-domain proteins are respectively associated
with inactive and active states of fundamental cellular pathways. The HORMA protein O …

The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment
and promotes checkpoint signaling to ensure accurate chromosome segregation. The …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

Error-free chromosome segregation relies on stable connections between kinetochores and
spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections …

In mitosis, for each daughter cell to inherit an accurate copy of the genome from the mother
cell, sister chromatids in the mother cell must attach to microtubules emanating from …

The anaphase-promoting complex or cyclosome (APC/C) is the ubiquitin ligase that
regulates mitosis by targeting specific proteins for degradation at specific times under the …