Targeting macrophages: a novel treatment strategy in solid tumors

M Liu, L Liu, Y Song, W Li, L Xu - Journal of Translational Medicine, 2022 - Springer
In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …

Insights into the tumor microenvironment of B cell lymphoma

WL Ng, SM Ansell, P Mondello - Journal of Experimental & Clinical Cancer …, 2022 - Springer
The standard therapies in lymphoma have predominantly focused on targeting tumor cells
with less of a focus on the tumor microenvironment (TME), which plays a critical role in …

A Semiconducting Iron‐Chelating Nano‐immunomodulator for Specific and Sensitized Sono‐metallo‐immunotherapy of Cancer

S He, J Yu, M Xu, C Zhang, C Xu… - Angewandte …, 2023 - Wiley Online Library
Sono‐immunotherapy holds great potential for deep tumor inhibition; however, smart sono‐
therapeutic agents to simultaneously eliminate 'domestic'tumor cells and regulate the …

A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses

F Araujo-Ayala, C Dobaño-López, JG Valero, F Nadeu… - Leukemia, 2023 - nature.com
Mantle cell lymphoma (MCL), a rare and aggressive B-cell non-Hodgkin lymphoma, mainly
develops in the lymph node (LN) and creates a protective and immunosuppressive niche …

Follicular lymphoma: The long and winding road leading to your cure?

MJ Gordon, MR Smith, LJ Nastoupil - Blood Reviews, 2023 - Elsevier
Follicular lymphoma, the most common indolent lymphoma, though highly responsive to
therapy is coupled with multiple relapses for the majority of patients. Advances in biologic …

[HTML][HTML] Evaluation of cell membrane-derived nanoparticles as therapeutic carriers for pancreatic ductal adenocarcinoma using an in vitro tumour stroma model

C Tapeinos, G Torrieri, S Wang, JP Martins… - Journal of Controlled …, 2023 - Elsevier
Here, we fabricated nanoparticles made solely from the membrane of cells found in the
pancreatic tumour's microenvironment (TME), like the human MiaPaCa-2 cells and M2 …

Safety of immune checkpoint inhibitors in elderly patients: an observational study

A Paderi, S Fancelli, E Caliman, S Pillozzi, E Gambale… - Current …, 2021 - mdpi.com
Background: Immunotherapy has completely changed the treatment of solid tumors.
Although immune checkpoint inhibitors (ICIs) seem to be an appealing alternative to …

Switch to phagocytic microglia by CSFR1 inhibition drives amyloid-beta clearance from glutamatergic terminals rescuing LTP in acute hippocampal slices

G Piccioni, N Maisto, A d'Ettorre, G Strimpakos… - Translational …, 2024 - nature.com
Microglia, traditionally regarded as innate immune cells in the brain, drive
neuroinflammation and synaptic dysfunctions in the early phases of Alzheimer disease (AD) …

Role and mechanisms of tumor-associated macrophages in hematological malignancies

Y Xie, H Yang, C Yang, L He, X Zhang, L Peng… - Frontiers in …, 2022 - frontiersin.org
Mounting evidence has revealed that many nontumor cells in the tumor microenvironment,
such as fibroblasts, endothelial cells, mesenchymal stem cells, and leukocytes, are strongly …

[HTML][HTML] Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages

M Zhu, L Bai, X Liu, S Peng, Y Xie, H Bai… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase
receptor, has been identified as a proto-oncogene in multiple cancers. The CSF1/CSF1R …