Targeting macrophages: a novel treatment strategy in solid tumors
M Liu, L Liu, Y Song, W Li, L Xu - Journal of Translational Medicine, 2022 - Springer
In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …
abundant immune cells, which act as a key regulator in tumorigenesis and progression …
Insights into the tumor microenvironment of B cell lymphoma
WL Ng, SM Ansell, P Mondello - Journal of Experimental & Clinical Cancer …, 2022 - Springer
The standard therapies in lymphoma have predominantly focused on targeting tumor cells
with less of a focus on the tumor microenvironment (TME), which plays a critical role in …
with less of a focus on the tumor microenvironment (TME), which plays a critical role in …
A Semiconducting Iron‐Chelating Nano‐immunomodulator for Specific and Sensitized Sono‐metallo‐immunotherapy of Cancer
Sono‐immunotherapy holds great potential for deep tumor inhibition; however, smart sono‐
therapeutic agents to simultaneously eliminate 'domestic'tumor cells and regulate the …
therapeutic agents to simultaneously eliminate 'domestic'tumor cells and regulate the …
A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses
Mantle cell lymphoma (MCL), a rare and aggressive B-cell non-Hodgkin lymphoma, mainly
develops in the lymph node (LN) and creates a protective and immunosuppressive niche …
develops in the lymph node (LN) and creates a protective and immunosuppressive niche …
Follicular lymphoma: The long and winding road leading to your cure?
Follicular lymphoma, the most common indolent lymphoma, though highly responsive to
therapy is coupled with multiple relapses for the majority of patients. Advances in biologic …
therapy is coupled with multiple relapses for the majority of patients. Advances in biologic …
[HTML][HTML] Evaluation of cell membrane-derived nanoparticles as therapeutic carriers for pancreatic ductal adenocarcinoma using an in vitro tumour stroma model
Here, we fabricated nanoparticles made solely from the membrane of cells found in the
pancreatic tumour's microenvironment (TME), like the human MiaPaCa-2 cells and M2 …
pancreatic tumour's microenvironment (TME), like the human MiaPaCa-2 cells and M2 …
Safety of immune checkpoint inhibitors in elderly patients: an observational study
A Paderi, S Fancelli, E Caliman, S Pillozzi, E Gambale… - Current …, 2021 - mdpi.com
Background: Immunotherapy has completely changed the treatment of solid tumors.
Although immune checkpoint inhibitors (ICIs) seem to be an appealing alternative to …
Although immune checkpoint inhibitors (ICIs) seem to be an appealing alternative to …
Switch to phagocytic microglia by CSFR1 inhibition drives amyloid-beta clearance from glutamatergic terminals rescuing LTP in acute hippocampal slices
G Piccioni, N Maisto, A d'Ettorre, G Strimpakos… - Translational …, 2024 - nature.com
Microglia, traditionally regarded as innate immune cells in the brain, drive
neuroinflammation and synaptic dysfunctions in the early phases of Alzheimer disease (AD) …
neuroinflammation and synaptic dysfunctions in the early phases of Alzheimer disease (AD) …
Role and mechanisms of tumor-associated macrophages in hematological malignancies
Y Xie, H Yang, C Yang, L He, X Zhang, L Peng… - Frontiers in …, 2022 - frontiersin.org
Mounting evidence has revealed that many nontumor cells in the tumor microenvironment,
such as fibroblasts, endothelial cells, mesenchymal stem cells, and leukocytes, are strongly …
such as fibroblasts, endothelial cells, mesenchymal stem cells, and leukocytes, are strongly …
[HTML][HTML] Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages
M Zhu, L Bai, X Liu, S Peng, Y Xie, H Bai… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase
receptor, has been identified as a proto-oncogene in multiple cancers. The CSF1/CSF1R …
receptor, has been identified as a proto-oncogene in multiple cancers. The CSF1/CSF1R …