The NLRP3 inflammasome is a multi-protein complex that initiates innate immunity
responses when exposed to a wide range of stimuli, including pathogen-associated …

Background Neurodegenerative diseases are a common group of neurological disorders
characterized by progressive loss of neuronal structure and function leading to cognitive …

NLRP3 is an important pattern recognition receptor in the innate immune system, and its
activation induces a large number of pro-inflammatory cytokines, IL-1β and IL-18 which are …

The CNS is very susceptible to oxidative stress; the gut microbiota plays an important role as
a trigger of oxidative damage that promotes mitochondrial dysfunction, neuroinflammation …

Epoxyeicosatrienoic acids (EETs) derived from arachidonic acid exert anti‐inflammation
effects. We have reported that blocking the degradation of EETs with a soluble epoxide …

Autophagy selectively degrades aggregation-prone misfolded proteins caused by defective
cellular proteostasis. However, the complexity of autophagy may prevent the full …

Targeting NLRP3 inflammasome with inhibitors is a novel strategy for NLRP3-driven
diseases. Herein, hit compound 5 possessing an attractive skeleton was identified from our …

Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and
IL-18 cytokines that trigger inflammatory responses against damage-associated molecular …

Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense
mechanism against microbial infections. Although Chlamydia has been shown to induce …

Systemic sclerosis (SSc) is an autoimmune rheumatic disease with high mortality, which is
featured by inflammation, vascular damage, and aggressive fibrosis. To date, the …