Oral and gastrointestinal mucositis is a toxicity of many forms of radiotherapy and
chemotherapy. It has a significant impact on health, quality of life and economic outcomes …

BACKGROUND A frequent complication of anticancer treatment, oral and gastrointestinal
(GI) mucositis, threatens the effectiveness of therapy because it leads to dose reductions …

Acute Lymphoblastic Leukemia | New England Journal of Medicine Skip to main content Access
provided by Charite - Universitaetsmedizin Berlin The New England Journal of Medicine …

More is known about the metabolism, toxicity, pharmacokinetics, and clinical profile of
methotrexate (MTX) than any other drug currently in use in either rheumatology or oncology …

Oral mucositis (OM) has emerged as a common cause of dose delays and interruptions of
cancer therapies such as multicycle chemotherapy, myeloablative chemotherapy, and …

Objective Methotrexate (MTX) enters cells through the reduced folate carrier (RFC‐1) and
exerts part of its effects through polyglutamation to MTX polyglutamates (MTXPGs) and …

As the cure rates for haematological malignancies have improved, the exploration of the
balance between efficacy and side effects has become a major research target. The …

Oral mucositis induced by radiation therapy and chemotherapy is a frequently occurring
toxicity in patients with cancer. Severe mucositis has a major impact on patient daily …

Methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism,
has two common polymorphisms that affect enzyme activity. The objective of this study was …

The use of combination chemotherapy to cure acute lymphoblastic leukaemia (ALL) in
children emerged in the 1980s as a paradigm for curing any disseminated cancer, and many …