Phagocytosis: a fundamental process in immunity
C Rosales, E Uribe-Querol - BioMed research international, 2017 - Wiley Online Library
One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …
the first to observe the uptake of particles by cells and realized the importance of this …
Control of phagocytosis by microbial pathogens
E Uribe-Querol, C Rosales - Frontiers in immunology, 2017 - frontiersin.org
Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …
unicellular organisms such as free-living amoeba use this process to acquire food. In …
The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease
S Hartmann, AJ Ridley, S Lutz - Frontiers in pharmacology, 2015 - frontiersin.org
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
Targeting Rac and Cdc42 GEFs in metastatic cancer
MDM Maldonado, JI Medina, L Velazquez… - Frontiers in cell and …, 2020 - frontiersin.org
The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …
Evolution of therapies for the corneal endothelium: past, present and future approaches
Corneal endothelial diseases are leading indications for corneal transplantations. With
significant advancement in medical science and surgical techniques, corneal transplant …
significant advancement in medical science and surgical techniques, corneal transplant …
Taking aim at moving targets in computational cell migration
Cell migration is central to the development and maintenance of multicellular organisms.
Fundamental understanding of cell migration can, for example, direct novel therapeutic …
Fundamental understanding of cell migration can, for example, direct novel therapeutic …
Drugging the small GTPase pathways in cancer treatment: promises and challenges
N Prieto-Dominguez, C Parnell, Y Teng - Cells, 2019 - mdpi.com
Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle
between an inactive state when bound to GDP and an active state when associated to GTP …
between an inactive state when bound to GDP and an active state when associated to GTP …
Compartmentalisation of RAC1 signalling
A Payapilly, A Malliri - Current opinion in cell biology, 2018 - Elsevier
RAC1 signalling has been implicated in a variety of dynamic cell biological processes that
are orchestrated through regulated localisation and activation of RAC1. As a small GTPase …
are orchestrated through regulated localisation and activation of RAC1. As a small GTPase …
Rho GTPases: Anti-or pro-neoplastic targets?
I Zandvakili, Y Lin, JC Morris, Y Zheng - Oncogene, 2017 - nature.com
Rho GTPases are critical signal transducers of multiple pathways. They have been
proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven …
proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven …
Identification of AnnexinA1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes
Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays
an important role in the pathophysiology of diseases associated with chronic inflammation …
an important role in the pathophysiology of diseases associated with chronic inflammation …