One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …

Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer
metastasis, due to their essential roles in regulating cell division and actin cytoskeletal …

Corneal endothelial diseases are leading indications for corneal transplantations. With
significant advancement in medical science and surgical techniques, corneal transplant …

Cell migration is central to the development and maintenance of multicellular organisms.
Fundamental understanding of cell migration can, for example, direct novel therapeutic …

Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle
between an inactive state when bound to GDP and an active state when associated to GTP …

RAC1 signalling has been implicated in a variety of dynamic cell biological processes that
are orchestrated through regulated localisation and activation of RAC1. As a small GTPase …

Rho GTPases are critical signal transducers of multiple pathways. They have been
proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven …

Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays
an important role in the pathophysiology of diseases associated with chronic inflammation …