Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or
radiation administered for a primary condition, typically a malignant disease, solid organ …

Context Testicular germ-cell tumors (GCT) are highly curable. A multidisciplinary approach,
including cisplatin-based chemotherapy has resulted in cure in the majority of patients with …

The introduction of advanced techniques and technology in radiotherapy has greatly
improved our ability to deliver highly conformal tumor doses while minimizing the dose to …

Importance Hodgkin lymphoma (HL) survivors are at increased risk of cardiovascular
diseases. It is unclear, however, how long the increased risk persists and what the risk …

Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The
signatures of mutations arising in human tissues following in vivo exposure to ionizing …

Background: Studies of cardiac disease among adult survivors of childhood cancer have
generally relied on self-reported or registry-based data. Objective: To systematically assess …

Improvements in early detection, supportive care, and treatment have resulted in an
increasing number of cancer survivors, with a current 5-year relative survival rate for all …

Second and higher-order malignancies now comprise about 18% of all incident cancers in
the USA, superseding first primary cancers of the breast, lung, and prostate. The occurrence …

Purpose: To review the data concerning the role of endogenously generated reactive
oxygen species (ROS) in the non-targeted ionizing radiation (IR) effects and in …

Simple Summary Childhood cancers are mostly of unknown etiology and represent
devastating diagnoses. The clinical benefits of steadily increasing tumor control and survival …