Organization and regulation of mitochondrial protein synthesis
Mitochondria are essential organelles of endosymbiotic origin that are responsible for
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …
[HTML][HTML] Regulation of mammalian mitochondrial gene expression: recent advances
SF Pearce, P Rebelo-Guiomar, AR D'Souza… - Trends in biochemical …, 2017 - cell.com
Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human
pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial …
pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial …
[HTML][HTML] Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
L Van Haute, S Dietmann, L Kremer, S Hussain… - Nature …, 2016 - nature.com
Epitranscriptome modifications are required for structure and function of RNA and defects in
these pathways have been associated with human disease. Here we identify the RNA target …
these pathways have been associated with human disease. Here we identify the RNA target …
NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
L Van Haute, SY Lee, BJ McCann… - Nucleic acids …, 2019 - academic.oup.com
Expression of human mitochondrial DNA is indispensable for proper function of the oxidative
phosphorylation machinery. The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 …
phosphorylation machinery. The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 …
METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis
LV Haute, AG Hendrick, AR D'Souza… - Nucleic acids …, 2019 - academic.oup.com
Post-transcriptional RNA modifications, the epitranscriptome, play important roles in
modulating the functions of RNA species. Modifications of rRNA are key for ribosome …
modulating the functions of RNA species. Modifications of rRNA are key for ribosome …
[HTML][HTML] Human mitochondrial RNA processing and modifications: overview
M Jedynak-Slyvka, A Jabczynska… - International Journal of …, 2021 - mdpi.com
Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are
present in almost all eukaryotic organisms, including humans. They are the key energy …
present in almost all eukaryotic organisms, including humans. They are the key energy …
Mitochondrial dysfunction: an emerging link in the pathophysiology of polycystic ovary syndrome
P Shukla, S Mukherjee - Mitochondrion, 2020 - Elsevier
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by
irregular menstrual cycles, hyperandrogenism and subfertility. Due to its complex …
irregular menstrual cycles, hyperandrogenism and subfertility. Due to its complex …
Monitoring mitochondrial translation in living cells
Mitochondria possess a small genome that codes for core subunits of the oxidative
phosphorylation system and whose expression is essential for energy production …
phosphorylation system and whose expression is essential for energy production …
[HTML][HTML] Transcription, processing, and decay of mitochondrial RNA in health and disease
A Barchiesi, C Vascotto - International journal of molecular sciences, 2019 - mdpi.com
Although the large majority of mitochondrial proteins are nuclear encoded, for their correct
functioning mitochondria require the expression of 13 proteins, two rRNA, and 22 tRNA …
functioning mitochondria require the expression of 13 proteins, two rRNA, and 22 tRNA …
[HTML][HTML] Mitochondrial gene expression and beyond—novel aspects of cellular physiology
AV Kotrys, RJ Szczesny - Cells, 2019 - mdpi.com
Mitochondria are peculiar organelles whose proper function depends on the crosstalk
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …