Chronic diseases that affect our society are made more complex by comorbidities and are
poorly managed by the current pharmacology. While all present inflammatory …

The formyl peptide receptor (FPR) family is involved in host defence against pathogens, but
also in sensing internal molecules that may constitute signals of cellular dysfunction. It …

Lipoxins (LXs) and aspirin-triggered LX (ATL) are trihydroxytetraene-containing eicosanoids
generated from arachidonic acid that are distinct in structure, formation, and function from …

The human formyl-peptide receptor (FPR)-2 is a G protein-coupled receptor that transduces
signals from lipoxin A 4, annexin A1, and serum amyloid A (SAA) to regulate inflammation. In …

The annexin superfamily consists of 13 calcium or calcium and phospholipid binding
proteins with a significant degree of biological and structural homology (40–60%). First …

Background: Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular
diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory …

Inflammation is the body's way of defending itself against noxious stimuli and pathogens.
Under normal circumstances, the body is able to eliminate the insult and subsequently …

Background—Platelet activation at sites of vascular injury is essential for hemostasis, but it is
also a major pathomechanism underlying ischemic injury. Because anti-inflammatory …

The glucocorticoids are the most potent anti‐inflammatory drugs that we possess and are
effective in a wide variety of diseases. Although their action is known to involve receptor …

Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical
need. Formyl peptide receptors (FPR) regulate inflammation, a major contributing …