Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …

Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …

Microorganisms produce small bioactive compounds as part of their secondary or
specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal …

Many microorganisms produce natural products that form the basis of antimicrobials,
antivirals, and other drugs. Genome mining is routinely used to complement screening …

The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has
enabled insights into the ecology and evolution of environmental and host-associated …

Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …

Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …