Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
Molecular heterogeneity and immunosuppressive microenvironment in glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …
STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma
As a key component of the standard of care for glioblastoma, radiotherapy induces several
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here …
immune resistance mechanisms, such as upregulation of CD47 and PD-L1. Here …
Immune suppression in gliomas
Introduction The overall survival in patients with gliomas has not significantly increased in
the modern era, despite advances such as immunotherapy. This is in part due to their …
the modern era, despite advances such as immunotherapy. This is in part due to their …
Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies
AR Pombo Antunes, I Scheyltjens, J Duerinck, B Neyns… - Elife, 2020 - elifesciences.org
Cancer immunotherapy by immune checkpoint blockade has proven its great potential by
saving the lives of a proportion of late stage patients with immunogenic tumor types …
saving the lives of a proportion of late stage patients with immunogenic tumor types …
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas
JA Flores-Toro, D Luo, A Gopinath… - Proceedings of the …, 2020 - National Acad Sciences
Immunotherapy directed at the PD-L1/PD-1 axis has produced treatment advances in
various human cancers. Unfortunately, progress has not extended to glioblastoma (GBM) …
various human cancers. Unfortunately, progress has not extended to glioblastoma (GBM) …
Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner
Myeloid-derived suppressor cells (MDSC) that block antitumor immunity are elevated in
glioblastoma (GBM) patient blood and tumors. However, the distinct contributions of …
glioblastoma (GBM) patient blood and tumors. However, the distinct contributions of …
Myeloid cells in glioblastoma microenvironment
Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …
Mass cytometry detects H3. 3K27M-specific vaccine responses in diffuse midline glioma
S Mueller, JM Taitt… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND Patients with diffuse midline gliomas (DMGs), including diffuse intrinsic
pontine glioma (DIPG), have dismal outcomes. We previously described the H3. 3K27M …
pontine glioma (DIPG), have dismal outcomes. We previously described the H3. 3K27M …
Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma
Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in
high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate …
high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate …