The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic
microenvironment in malignant invasion. This microenvironment is acidified primarily by the …

A key cellular process associated with the invasive or metastatic program in many cancers is
the transformation of epithelial cells toward a mesenchymal state, a process called epithelial …

Acidic tissue microenvironment contributes to tumor progression via multiple effects
including the activation of angiogenic factors and proteases, reduced cell-cell adhesion …

The epidermal growth factor receptor (ErbB1 or EGFR) has been found to be altered in a
variety of human cancers. A number of agents targeting these receptors, including specific …

Invadopodia are invasive protrusions with proteolytic activity uniquely found in tumor cells.
Cortactin phosphorylation is a key step during invadopodia maturation, regulating Nck1 …

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities
for therapeutic intervention. The acidic microenvironment within a tumour can promote …

Cancer accounts for 13% of the yearly total mortality worldwide. Most cancer deaths are the
sequel of metastatic diseases rather than of primary tumor growth. Thus, the major challenge …

Background An increasing number of studies have demonstrated that long non-coding
RNAs (lncRNAs) play pivotal roles in cancer onset and development. LncRNA AFAP1-AS1 …