Kléber, André G., and Yoram Rudy. Basic Mechanisms of Cardiac Impulse Propagation and
Associated Arrhythmias. Physiol Rev 84: 431–488, 2004; 10.1152/physrev. 00025.2003 …

Gap junctions are a unique type of intercellular junction found in most animal cell types. Gap
junctions permit the intercellular passage of small molecules and have been implicated in …

Objective: We tested the hypothesis that structural remodeling of cellular connections,
alterations in the expression of connexins (Cx), and an increase in fibrosis represent …

Remodeling of the distribution of gap junctions is an important feature of anatomic
substrates of arrhythmias in patients with healed myocardial infarcts. Mechanisms …

Slowed myocardial conduction velocity (θ) is associated with an increased risk of re-entrant
excitation, predisposing to cardiac arrhythmia. θ is determined by the ion channel and …

The posttranscriptional regulator, microRNA-21 (miR-21), is up-regulated in many forms of
cancer, as well as during cardiac hypertrophic growth. To understand its role, we …

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …

Congestive heart failure is associated with a high risk of life-threatening ventricular re-
entrant arrhythmias. Down-regulation of the principal gap-junctional protein of the ventricular …

Gap junction channels composed of connexin43 (Cx43) are essential for normal heart
formation and function. We studied the potential role of the Wnt family of secreted …

Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …