Benefits of zebrafish xenograft models in cancer research

X Chen, Y Li, T Yao, R Jia - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …

Preclinical models of glioblastoma: Limitations of current models and the promise of new developments

P Liu, S Griffiths, D Veljanoski… - Expert Reviews in …, 2021 - cambridge.org
Glioblastoma (GBM) is the most common and aggressive primary brain tumour, yet little
progress has been made towards providing better treatment options for patients diagnosed …

[HTML][HTML] Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines

B Breznik, H Motaln, M Vittori, A Rotter, TL Turnšek - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma multiforme are an aggressive form of brain tumors that are characterized by
distinct invasion of single glioblastoma cells, which infiltrate the brain parenchyma. This …

Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

L Finotto, B Cole, W Giese, E Baumann… - EMBO Molecular …, 2023 - embopress.org
Glioblastoma (GBM) remains the most malignant primary brain tumor, with a median survival
rarely exceeding 2 years. Tumor heterogeneity and an immunosuppressive …

TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma

C Giallongo, D Tibullo, G Camiolo, NL Parrinello… - Cell death & …, 2019 - nature.com
Inflammation represents a key feature and hallmark of tumor microenvironment playing a
major role in the interaction with mesenchymal stromal cells (MSC) in cancer progression …

TRIM28 selective nanobody reduces glioblastoma stem cell invasion

A Porčnik, M Novak, B Breznik, B Majc, B Hrastar… - Molecules, 2021 - mdpi.com
Glioblastoma (GB), is the most common and aggressive malignant primary brain tumour in
adults. Intra-and inter-tumour heterogeneity, infiltrative GB cell invasion and presence of …

Identify a blood-brain barrier penetrating drug-TNB using zebrafish orthotopic glioblastoma xenograft model

A Zeng, T Ye, D Cao, X Huang, Y Yang, X Chen… - Scientific reports, 2017 - nature.com
The blood–brain barrier (BBB) is necessary for maintaining brain homeostasis, but it also
represents a major challenge for drug delivery to the brain tumors. A suitable in vivo …

Cellular and molecular mechanisms underlying glioblastoma and zebrafish models for the discovery of new treatments

P Reimunde, A Pensado-López, M Carreira Crende… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is one of the greatest challenges facing neuro-
oncology today. Current treatments are far from satisfactory and, given the poor prognosis of …

Three-dimensional imaging in stem cell-based researches

F Nowzari, H Wang, A Khoradmehr… - Frontiers in Veterinary …, 2021 - frontiersin.org
Stem cells have an important role in regenerative therapies, developmental biology studies
and drug screening. Basic and translational research in stem cell technology needs more …

Zebrafish in translational cancer research: insight into leukemia, melanoma, glioma and endocrine tumor biology

AI Idilli, F Precazzini, MC Mione, V Anelli - Genes, 2017 - mdpi.com
Over the past 15 years, zebrafish have emerged as a powerful tool for studying human
cancers. Transgenic techniques have been employed to model different types of tumors …