Pulmonary hypertension is a common hemodynamic complication of heart failure. Interest in
left-sided pulmonary hypertension has increased remarkably in recent years because its …

Caveolae, a subset of membrane (lipid) rafts, are flask-like invaginations of the plasma
membrane that contain caveolin proteins, which serve as organizing centers for cellular …

In 1889, Dr. Stephen Paget proposed the “seed and soil” hypothesis, which states that
cancer cells (the seeds) need the proper microenvironment (the soil) for them to grow …

Elevation of intracranial soluble amyloid-β (Aβ) levels has been implicated in the
pathogenesis of Alzheimer's disease (AD). Intracellular events in neurons, which lead to …

Background—Pulmonary arterial hypertension (PAH) is a hyperproliferative vascular
disorder observed predominantly in women. Estrogen is a potent mitogen in human …

The development of pulmonary hypertension (PH) is common and has adverse prognostic
implications in patients with heart failure due to left heart disease (LHD), and thus far, there …

Toxoplasma gondii uracil phosphoribosyltransferase (UPRT) converts 4‐thiouracil (4TUc)
into 4‐thiouridine (4TUd), which is incorporated into nascent RNAs and can be biotinylated …

Background: Amyloid β (Aβ) has long been implicated in the pathogenesis of Alzheimer's
disease (AD). Little is known, however, about the intracellular events in neurons which lead …

Vasoconstriction and vascular medial hypertrophy, resulting from increased intracellular
[Ca2+] in pulmonary artery smooth muscle cells (PASMC), contribute to elevated vascular …

We show here that the apposition of plasma membrane caveolae and mitochondria (first
noted in electron micrographs> 50 yr ago) and caveolae-mitochondria interaction regulates …