[HTML][HTML] Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
Self-organizing 3D human trunk neuromuscular organoids
JMF Martins, C Fischer, A Urzi, R Vidal, S Kunz… - Cell stem cell, 2020 - cell.com
Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …
essential for the control of body movement. Previous neuromuscular junction modeling …
Modeling sporadic Alzheimer's disease in human brain organoids under serum exposure
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure. Huge
efforts have been made to develop anti‐AD drugs in the past decades. However, all drug …
efforts have been made to develop anti‐AD drugs in the past decades. However, all drug …
In-vivo programmable acoustic manipulation of genetically engineered bacteria
Acoustic tweezers can control target movement through the momentum interaction between
an acoustic wave and an object. This technology has advantages over optical tweezers for …
an acoustic wave and an object. This technology has advantages over optical tweezers for …
[HTML][HTML] Longevity leap: mind the healthspan gap
A Garmany, S Yamada, A Terzic - NPJ Regenerative Medicine, 2021 - nature.com
Life expectancy has increased by three decades since the mid-twentieth century. Parallel
healthspan expansion has however not followed, largely impeded by the pandemic of …
healthspan expansion has however not followed, largely impeded by the pandemic of …
Strategies to reduce the risks of mRNA drug and vaccine toxicity
D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …
enabled the rapid development and administration of billions of coronavirus disease 2019 …
Advances in engineering human tissue models
CM Moysidou, C Barberio, RM Owens - Frontiers in bioengineering …, 2021 - frontiersin.org
Research in cell biology greatly relies on cell-based in vitro assays and models that facilitate
the investigation and understanding of specific biological events and processes under …
the investigation and understanding of specific biological events and processes under …
Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis
J Deinsberger, D Reisinger, B Weber - NPJ Regenerative medicine, 2020 - nature.com
Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to
regenerate or replace functionally impaired tissues. Since the introduction of the induced …
regenerate or replace functionally impaired tissues. Since the introduction of the induced …
CRISPR modeling and correction of cardiovascular disease
Cardiovascular disease remains the leading cause of morbidity and mortality in the
developed world. In recent decades, extraordinary effort has been devoted to defining the …
developed world. In recent decades, extraordinary effort has been devoted to defining the …