Next generation and other sequencing technologies in diagnostic microbiology and infectious diseases

EE Hilt, P Ferrieri - Genes, 2022 - mdpi.com
Next-generation sequencing (NGS) technologies have become increasingly available for
use in the clinical microbiology diagnostic environment. There are three main applications of …

Clostridioides difficile infection in children: Recent updates on epidemiology, diagnosis, therapy

DA Shirley, W Tornel, CA Warren, S Moonah - Pediatrics, 2023 - publications.aap.org
Clostridioides (formerly Clostridium) difficile is the most important infectious cause of
antibiotic-associated diarrhea worldwide and a leading cause of healthcare-associated …

Strategies to prevent Clostridioides difficile infections in acute-care hospitals: 2022 update

LK Kociolek, DN Gerding, R Carrico… - Infection Control & …, 2023 - cambridge.org
Objective Previously published guidelines provided comprehensive recommendations for
detecting and preventing healthcare-associated infections (HAIs). The intent of this …

Genomic features associated with the degree of phenotypic resistance to carbapenems in carbapenem-resistant Klebsiella pneumoniae

ZP Bulman, F Krapp, NB Pincus, E Wenzler… - Msystems, 2021 - Am Soc Microbiol
Carbapenem-resistant Klebsiella pneumoniae strains cause severe infections that are
difficult to treat. The production of carbapenemases such as the K. pneumoniae …

Natural Clostridioides difficile Toxin Immunization in Colonized Infants

LK Kociolek, RO Espinosa, DN Gerding… - Clinical Infectious …, 2020 - academic.oup.com
Abstract Background Clostridioides (Clostridium) difficile colonization is common among
infants. Serological sequelae of infant C. difficile colonization are poorly understood …

[HTML][HTML] Development and implementation of whole genome sequencing-based typing schemes for Clostridioides difficile

S Janezic, M Rupnik - Frontiers in Public Health, 2019 - frontiersin.org
Clostridioides difficile is an important nosocomial pathogen increasingly observed in the
community and in different non-human reservoirs. The epidemiology and transmissibility of …

Identification of Clostridium innocuum hypothetical protein that is cross-reactive with C. difficile anti-toxin antibodies

KE Cherny, A Balaji, J Mukherjee, YA Goo, AR Hauser… - Anaerobe, 2022 - Elsevier
Objectives Previously considered solely an opportunistic pathogen, Clostridium innocuum
(CI) was recently reported in Taiwan to be an emerging cause of antibiotic-associated …

Diarrhoeal events can trigger long-term Clostridium difficile colonization with recurrent blooms

D VanInsberghe, JA Elsherbini, B Varian… - Nature …, 2020 - nature.com
Although Clostridium difficile is widely considered an antibiotic-and hospital-associated
pathogen, recent evidence indicates that this is an insufficient depiction of the risks and …

Whole-genome sequencing reveals the high nosocomial transmission and antimicrobial resistance of Clostridioides difficile in a single center in China, a four-year …

X Wen, C Shen, J Xia, LL Zhong, Z Wu… - Microbiology …, 2022 - Am Soc Microbiol
Clostridioides difficile, which causes life-threatening diarrheal disease, presents an urgent
threat to health care systems. In this study, we present a retrospective genomic and …

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …