Sex differences in severity and mortality from COVID-19: are males more vulnerable?
A Pradhan, PE Olsson - Biology of sex Differences, 2020 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates
all over the world, and despite the global efforts, there is so far no specific therapy available …
all over the world, and despite the global efforts, there is so far no specific therapy available …
[HTML][HTML] Androgen-induced immunosuppression
MR Gubbels Bupp, TN Jorgensen - Frontiers in immunology, 2018 - frontiersin.org
In addition to determining biological sex, sex hormones are known to influence health and
disease via regulation of immune cell activities and modulation of target-organ susceptibility …
disease via regulation of immune cell activities and modulation of target-organ susceptibility …
TFOS DEWS II sex, gender, and hormones report
One of the most compelling features of dry eye disease (DED) is that it occurs more
frequently in women than men. In fact, the female sex is a significant risk factor for the …
frequently in women than men. In fact, the female sex is a significant risk factor for the …
[HTML][HTML] Gender differences in autoimmune disease
Autoimmune diseases are a range of diseases in which the immune response to self-
antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …
antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
Females have generally more robust immune responses than males for reasons that are not
well-understood. Here we used a systems analysis to investigate these differences by …
well-understood. Here we used a systems analysis to investigate these differences by …
Estrogen and COVID-19 symptoms: associations in women from the COVID Symptom Study
R Costeira, KA Lee, B Murray, C Christiansen… - PLoS …, 2021 - journals.plos.org
It has been widely observed that adult men of all ages are at higher risk of developing
serious complications from COVID-19 when compared with women. This study aimed to …
serious complications from COVID-19 when compared with women. This study aimed to …
Glucocorticoids, sex hormones, and immunity
O Bereshchenko, S Bruscoli, C Riccardi - Frontiers in immunology, 2018 - frontiersin.org
Glucocorticoid hormones regulate essential body functions in mammals, control cell
metabolism, growth, differentiation, and apoptosis. Importantly, they are potent suppressors …
metabolism, growth, differentiation, and apoptosis. Importantly, they are potent suppressors …
Sex differences in neurodevelopmental and neurodegenerative disorders: focus on microglial function and neuroinflammation during development
R Hanamsagar, SD Bilbo - The Journal of steroid biochemistry and …, 2016 - Elsevier
Several neurological conditions are associated with sex differences in prevalence or
outcome. For example, autism predominantly affects boys, depression is more common in …
outcome. For example, autism predominantly affects boys, depression is more common in …
Gender differences in cancer susceptibility: an inadequately addressed issue
MT Dorak, E Karpuzoglu - Frontiers in genetics, 2012 - frontiersin.org
The gender difference in cancer susceptibility is one of the most consistent findings in
cancer epidemiology. Hematologic malignancies are generally more common in males and …
cancer epidemiology. Hematologic malignancies are generally more common in males and …
The Xs and Y of immune responses to viral vaccines
The biological differences associated with the sex of an individual are a major source of
variation, affecting immune responses to vaccination. Compelling clinical data illustrate that …
variation, affecting immune responses to vaccination. Compelling clinical data illustrate that …