T cells modified for expression of Chimeric Antigen Receptors (CARs) were the first gene-
modified cell products approved for use in cancer immunotherapy. CAR-T cells engineered …

Abnormal gene expression level or expression of genes containing deleterious mutations
are two of the main determinants which lead to genetic disease. To obtain a therapeutic …

Background Multiple genetic modifications may be required to develop potent off-the-shelf
chimeric antigen receptor (CAR) T cell therapies. Conventional CRISPR-Cas nucleases …

Regulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of
immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex …

CAR (Chimeric Antigen Receptor) T-cell therapy has revolutionized the field of oncology in
recent years. This innovative shift in cancer treatment also provides the opportunity to …

The dichotomic nature of the adaptive immune response governs the outcome of clinical
gene therapy. On the one hand, neutralizing antibodies and cytotoxic T cells can have a …

Regulatory Tcells (Treg) are essential components of peripheral immune homeostasis.
Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in …

Immunocompromised host section: Adoptive T-cell therapy for... : Current Opinion in
Infectious Diseases Immunocompromised host section: Adoptive T-cell therapy for dsDNA …

Rejection of solid organ transplant and graft versus host disease (GvHD) continue to be
challenging in post transplantation management. The introduction of calcineurin inhibitors …

Hematopoietic stem cell transplantation (HSCT) has been used as a curative standard of
care for moderate to severe primary immunodeficiency disorders as well as relapsed …