Biologics are an emerging class of medicines with substantial promise to treat neurological
disorders such as Alzheimer's disease, stroke, and multiple sclerosis. However, the blood …

More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

Lentiviral vectors (LVs) have emerged as potent and versatile vectors for ex vivo or in vivo
gene transfer into dividing and nondividing cells. Robust phenotypic correction of diseases …

The capacity to efficiently transduce nondividing cells, shuttle large genetic payloads, and
maintain stable long-term transgene expression are attributes that have brought lentiviral …

Naturally fluorescent proteins have revolutionized biology by enabling what was formerly
invisible to be seen clearly. These proteins have allowed us to visualize, in real time …

Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or
at least to improve the clinical status of a patient. One of the basic concepts of gene therapy …

Microinjection of DNA is now the most widespread method for generating transgenic
animals, but transgenesis rates achieved this way in higher mammals are extremely low. To …

Treatment of many neuronal degenerative disorders will require delivery of a therapeutic
protein to neurons or glial cells across the whole CNS. The presence of the blood–brain …

The close relationship between activation of blood coagulation and cancer is an old enigma.
In 1865, migrans trombophlebitis ('a condition of the blood that predisposes it to …

High-titer self-inactivating human immunodeficiency virus type-1 (HIV-1)–based vectors
expressing the green fluorescent protein reporter gene that contained the central polypurine …