Potent candidates for Targeted Auger Therapy: Production and radiochemical considerations

D Filosofov, E Kurakina, V Radchenko - Nuclear Medicine and Biology, 2021 - Elsevier
Abstract Targeted Auger Therapy represents great potential for the therapy of diseases
which require a high degree of selectivity on the cellular level (eg for therapy of metastatic …

The use of the macrocyclic chelator DOTA in radiochemical separations

Z Baranyai, G Tircsó, F Rösch - European Journal of Inorganic …, 2020 - Wiley Online Library
Radiometals play an important role in the diagnosis of physiological processes in vivo by
means of imaging technologies, but also increasingly contribute to the treatment of diseases …

Capturing an elusive but critical element: Natural protein enables actinium chemistry

GJP Deblonde, JA Mattocks, Z Dong, PT Wooddy… - Science …, 2021 - science.org
Actinium-based therapies could revolutionize cancer medicine but remain tantalizing due to
the difficulties in studying and limited knowledge of Ac chemistry. Current efforts focus on …

Including and declaring structural fluctuations in the study of Lanthanide (III) coordination chemistry in solution

LG Nielsen, TJ Sørensen - Inorganic chemistry, 2019 - ACS Publications
The physicochemical properties of lanthanide (III) ions are directly linked to the structure of
the surrounding ligands. Rapid ligand exchange prohibits direct structure–property …

H3nota Derivatives Possessing Picolyl and Picolinate Pendants for Ga3+ Coordination and 67Ga3+ Radiolabeling

A Marlin, A Koller, E Madarasi, M Cordier… - Inorganic …, 2023 - ACS Publications
We synthesized, thanks to the regiospecific N-functionalization using an orthoamide
intermediate, two 1, 4, 7-triazacyclononane derivatives containing an acetate arm and either …

Chelation with a twist: a bifunctional chelator to enable room temperature radiolabeling and targeted PET imaging with scandium-44

BA Vaughn, SH Ahn, E Aluicio-Sarduy, J Devaraj… - Chemical …, 2020 - pubs.rsc.org
Scandium-44 has emerged as an attractive, novel PET radioisotope with ideal emission
properties and half-life (t1/2= 3.97 h, Emean β+= 632 keV) well matched to the …

Production and use of the first-row transition metal PET radionuclides 43, 44Sc, 52Mn, and 45Ti

IF Chaple, SE Lapi - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
With the increasing focus on a more personalized approach to medicine using imaging
techniques to select patients for targeted treatment or theranostic strategies, interest in the …

Novel theranostic agent for PET imaging and targeted radiopharmaceutical therapy of tumour-infiltrating immune cells in glioma

A Foster, S Nigam, DS Tatum, I Raphael, J Xu… - …, 2021 - thelancet.com
Background Malignant gliomas are deadly tumours with few therapeutic options. Although
immunotherapy may be a promising therapeutic strategy for treating gliomas, a significant …

Development and Validation of an Analytical HPLC Method to Assess Chemical and Radiochemical Purity of [68Ga]Ga-NODAGA-Exendin-4 Produced by a Fully …

S Migliari, A Sammartano, M Boss, M Gotthardt… - Molecules, 2022 - mdpi.com
Background: Glucagon-like peptide 1 receptor (GLP-1R) is preferentially expressed in
pancreatic islets, especially in β-cells, and highly expressed in human insulinomas and …

Towards 213 Bi alpha-therapeutics and beyond: unravelling the foundations of efficient Bi III complexation by DOTP

D Horváth, F Travagin, N Guidolin… - Inorganic Chemistry …, 2021 - pubs.rsc.org
Bismuth isotopes are attracting increasing attention for their potential applications in
diagnostics and therapy. The emerging use of 213Bi in targeted α-therapy (TAT) is a …