Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Polarized trafficking is necessary for the development of eukaryotes and is regulated by a
conserved molecular machinery. Late steps of cargo delivery are mediated by the exocyst …

Experimental studies of protein-pattern formation have stimulated new interest in the
dynamics of reaction-diffusion systems. However, a comprehensive theoretical …

Lipid miscibility phase separation has long been considered to be a central element of cell
membrane organization. More recently, protein condensation phase transitions, into three …

The RhoGTPases are characterized as membrane-associated molecular switches that cycle
between active, GTP-bound and inactive, GDP-bound states. However, 90–95% of …

Located at the inner leaflet of the plasma membrane (PM), phosphatidyl-inositol 4, 5-
bisphosphate [PI (4, 5) P2] composes only 1–2 mol% of total PM lipids. With its synthesis …

ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

Signal transduction downstream of growth factor and immune receptor activation relies on
the production of phosphatidylinositol-(3, 4, 5)-trisphosphate (PI (3, 4, 5) P 3) lipids by PI3K …

During infection, intracellular bacterial pathogens translocate a variety of effectors into host
cells that modify host membrane trafficking for their benefit. We found a self-organizing …