Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

Hypertension (HTN) and chronic kidney disease (CKD) are increasingly recognized in
pediatric patients and represent risk factors for cardiovascular morbidity and mortality later in …

Bronchopulmonary dysplasia (BPD) is the leading cause of chronic lung disease in infants
and the commonest complication of prematurity. Advances in respiratory and overall …

α-Klotho protein is a powerful predictor of the aging process and lifespan. Although lowered
circulating soluble α-Klotho levels have been observed in aged non-healthy individuals, no …

Acute kidney injury (AKI) is associated with a very high mortality and an increased risk for
progression to chronic kidney disease (CKD). Ischemia-reperfusion injury (IRI) is a model for …

Oxidative stress driven by several environmental and local airway factors associated with
chronic obstructive bronchiolitis, a hallmark feature of COPD, plays a crucial role in disease …

Background α-Klotho is a pleiotropic protein that may have anti-oxidative and anti-
inflammatory properties in the lung, but its role in airflow obstruction or lung function is …

The nexus of chronic kidney disease (CKD) and cardiovascular disease (CVD) amplifies the
morbidity and mortality of CKD, emphasizing the need for defining and establishing …

Lymphangioleiomyomatosis (LAM) is a multisystem disease occurring in women of child-
bearing age manifested by uncontrolled proliferation of smooth muscle–like" LAM" cells in …

Oxidative stress occurs when there is an imbalance between reactive oxygen
species/reactive nitrogen species and antioxidant systems. The interplay between these …