There is an ongoing shift in demographics such that older persons will outnumber young
persons in the coming years, and with it age-associated tissue attrition and increased …

Neuroblastoma evolution, heterogeneity, and resistance remain inadequately defined,
suggesting a role for circulating tumor DNA (ctDNA) sequencing. To define the utility of …

Clonal hematopoiesis (CH) occurs in hematopoietic stem cells with increased risks of
progressing to hematologic malignancies. CH mutations are predominantly found in aged …

Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is
associated with increased risks of hematological malignancies. While TP53 mutations have …

The role of subclonal TP53 mutations, defined by a variant allele frequency of< 20%, has not
been addressed in acute myeloid leukemia yet. We, therefore, analyzed their prognostic …

TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in
myeloid malignancies with deletion of chromosome 5q. Employing a combination of …

Clonal haematopoiesis of indeterminate potential (CHIP) may predispose for the
development of therapy‐related myeloid neoplasms (t‐MN). Using target next‐generation …

Hematopoietic stem cells (HSCs) are sensitive to ionizing radiation (IR) damage, and its
injury is the primary cause of bone marrow (BM) hematopoietic failure and even death after …

TP53 mutations identified in CHIP are associated with increased risks of de novo and
therapy-related hematological neoplasms. Thus, targeting mutant p53 and related pathways …

Since the discovery of JAK2 V617F as a highly prevalent somatic acquired mutation in the
majority of myeloproliferative neoplasms (MPNs), it has become clear that these diseases …