Like other microorganisms, free-living Candida albicans is mainly present in a three-
dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form …

Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

Fungal infection has become one of the leading causes of hospital-acquired infections with
high mortality rates. Furthermore, drug resistance is common for fungus-causing diseases …

Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This
poses concern given the limited number of clinically useful antifungals and the growing …

All living organisms use numerous signal-transduction systems to sense and respond to
their environments and thereby survive and proliferate in a range of biological niches …

The survival of all organisms depends critically upon interactions with the environment,
mediated largely through the action of small molecules. Small molecules can provide the …

Candida albicans, one of the pathogenic Candida species, causes high mortality rate in
immunocompromised and high-risk surgical patients. In the last decade, only one new class …

The number of immunocompromised patients with invasive fungal infections continues to
increase and new antifungal therapies are not keeping pace with the growing incidence of …

There are relatively few classes of antifungal drugs. This restricts clinicians' therapeutic
choices and these choices are further reduced by the emergence of drug resistance …

In recent years, the emergence of fungal resistance has become frequent, partly due to the
widespread clinical use of fluconazole, which is minimally toxic and effective in the …