Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Amyloid precursor protein (APP) is a key molecule in the pathogenesis of Alzheimer's
disease (AD) as the pathogenic amyloid-β peptide is derived from it. Two closely related …

Mammalian SWI/SNF chromatin remodeling complexes move and evict nucleosomes at
gene promoters and enhancers to modulate DNA access. Although SWI/SNF subunits are …

Mammalian TIP60 is a multi-functional enzyme with histone acetylation and histone dimer
exchange activities. It plays roles in diverse cellular processes including transcription, DNA …

The human nucleosome acetyltransferase of histone H4 (NuA4)/Tat-interactive protein, 60
kilodalton (TIP60) coactivator complex, a fusion of the yeast switch/sucrose nonfermentable …

Early diets in honeybees have effects on epigenome with consequences on their phenotype.
Depending on the early larval diet, either royal jelly (RJ) or royal worker, 2 different female …

The lysine acetyltransferase KAT5 is a pivotal enzyme responsible for catalyzing histone H4
acetylation in cells. In addition to its indispensable HAT domain, KAT5 also encompasses a …

The proneural transcription factor ASCL1 regulates neurogenesis and drives somatic cell
reprogramming into neurons. However, not all cell types can be reprogrammed by ASCL1 …

The activation of YAP/TAZ, a pair of paralogs of transcriptional coactivators, initiates a
dysregulated transcription program, which is a key feature of human cancer cells. However …

Sepsis-associated encephalopathy (SAE) is a collection of clinical syndromes resulting from
sepsis and characterized by widespread brain dysfunction. The high prevalence of SAE has …