The post‐translational regulation of transcription factor EB (TFEB) in health and disease
M Takla, S Keshri, DC Rubinsztein - EMBO reports, 2023 - embopress.org
Transcription factor EB (TFEB) is a basic helix–loop–helix leucine zipper transcription factor
that acts as a master regulator of lysosomal biogenesis, lysosomal exocytosis, and macro …
that acts as a master regulator of lysosomal biogenesis, lysosomal exocytosis, and macro …
[HTML][HTML] Ragopathies and the rising influence of RagGTPases on human diseases
I Sambri, M Ferniani, A Ballabio - Nature Communications, 2024 - nature.com
RagGTPases (Rags) play an essential role in the regulation of cell metabolism by controlling
the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and …
the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and …
[HTML][HTML] microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression
X Chen, Y Cao, Y Guo, J Liu, X Ye, H Li, L Zhang… - Cellular …, 2024 - Elsevier
Atherosclerosis is characterised by lipid accumulation and formation of foam cells in arterial
walls. Dysregulated autophagy is a crucial factor in atherosclerosis development. The …
walls. Dysregulated autophagy is a crucial factor in atherosclerosis development. The …
[HTML][HTML] Heme oxygenase activates calcium release from the endoplasmic reticulum of bovine mammary epithelial cells to promote TFEB entry into the nucleus to …
M Xu, Z Zhu, S Meng, H Li, A Wang, HW Barkema… - Microbiological …, 2024 - Elsevier
Abstract Heme oxygenase HO-1 (HMOX) regulates cellular inflammation and apoptosis, but
its role in regulation of autophagy in Mycoplasma bovis infection is unknown. The objective …
its role in regulation of autophagy in Mycoplasma bovis infection is unknown. The objective …
RRAGD-associated autosomal dominant kidney hypomagnesemia with cardiomyopathy (ADKH-RRAGD): a review on the clinical manifestations and therapeutic …
F Trepiccione, I Sambri, B Ruggiero, F Emma… - Kidney & blood …, 2024 - karger.com
Background. A hereditary condition primarily affecting the kidneys and heart has newly been
identified: the RRAGD-associated Autosomal Dominant Kidney Hypomagnesemia with …
identified: the RRAGD-associated Autosomal Dominant Kidney Hypomagnesemia with …
Tissue‐specific expression differences in Ras‐related GTP‐binding proteins in male rats
GN Kincheloe, PA Roberson, LS Jefferson… - Physiological …, 2024 - Wiley Online Library
Abstract The protein kinase Mechanistic Target of Rapamycin (mTOR) in Complex 1
(mTORC1) is regulated in part by the Ras‐related GTP‐binding proteins (Rag GTPases) …
(mTORC1) is regulated in part by the Ras‐related GTP‐binding proteins (Rag GTPases) …
Dilated Cardiomyopathy With Concomitant Salt-Losing Renal Tubulopathy Caused by Heterozygous RRAGD Gene Variant
F de Frutos, C Diez-Lopez… - Circulation: Genomic …, 2024 - Am Heart Assoc
Around 40% of patients diagnosed with dilated car-diomyopathy (DCM) harbor an
underlying causative genetic variant, whereas the remaining cases are attributed to a …
underlying causative genetic variant, whereas the remaining cases are attributed to a …