Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Many human brain disorders are associated with characteristic alterations in the structural
and functional connectivity of the brain. In this article, we explore how commonalities and …

Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

The neurodevelopmental period spanning early-to-middle childhood represents a time of
significant growth and reorganisation throughout the cortex. Such changes are critical for the …

Brain function is a product of the balance between excitatory and inhibitory (E/I) brain
activity. Variation in the regulation of this activity is thought to give rise to normal variation in …

Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with
distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is …

Post-mortem studies allow for the direct investigation of brain tissue in those with autism and
related disorders. Several review articles have focused on aspects of post-mortem …

Atypical behavioral responses to environmental sounds are common in autistic children and
adults, with 50–70% of this population exhibiting decreased sound tolerance (DST) at some …

Computational psychiatry is a rapidly growing field attempting to translate advances in
computational neuroscience and machine learning into improved outcomes for patients …