Therapeutic strategies targeting FOXO transcription factors

G Calissi, EWF Lam, W Link - Nature reviews Drug discovery, 2021 - nature.com
FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Cancer and the circadian clock

AA Shafi, KE Knudsen - Cancer research, 2019 - AACR
The circadian clock is a master regulator of mammalian physiology, regulating daily
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …

An efficient method to isolate lemon derived extracellular vesicles for gastric cancer therapy

M Yang, X Liu, Q Luo, L Xu, F Chen - Journal of nanobiotechnology, 2020 - Springer
Background Plant-derived extracellular vesicles (PDEVs) have great potential for clinical
applications. Ultracentrifugation, considered the gold standard method for the preparation of …

Extracellular vesicles from plants: current knowledge and open questions

O Urzì, S Raimondo, R Alessandro - International Journal of Molecular …, 2021 - mdpi.com
The scientific interest in the beneficial properties of natural substances has been recognized
for decades, as well as the growing attention in extracellular vesicles (EVs) released by …

Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature

FM Millimouno, J Dong, L Yang, J Li, X Li - Cancer prevention research, 2014 - AACR
Although the incidences are increasing day after day, scientists and researchers taken
individually or by research group are trying to fight against cancer by several ways and also …

A review of common cyanotoxins and their effects on fish

H Falfushynska, N Kasianchuk, E Siemens, E Henao… - Toxics, 2023 - mdpi.com
Global warming and human-induced eutrophication drive the occurrence of various
cyanotoxins in aquatic environments. These metabolites reveal diversified mechanisms of …

Why is longevity still a scientific mystery? Sirtuins—past, present and future

P Ziętara, M Dziewięcka, M Augustyniak - International Journal of …, 2022 - mdpi.com
The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral

YJ Liew, D Zoccola, Y Li, E Tambutté, AA Venn… - Science …, 2018 - science.org
There are increasing concerns that the current rate of climate change might outpace the
ability of reef-building corals to adapt to future conditions. Work on model systems has …

DNA demethylation pathways: additional players and regulators

M Bochtler, A Kolano, GL Xu - Bioessays, 2017 - Wiley Online Library
DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …

Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages

JJ Zhu, P Ramanathan, EA Bishop, V O'Donnell… - PloS one, 2019 - journals.plos.org
African swine fever (ASF) is a swine disease caused by a large, structurally complex, double-
stranded DNA virus, African swine fever virus (ASFV). In domestic pigs, acute infection by …