Chemokines are small secretory chemotactic cytokines that control the directed migration of
immune cells. Chemokines are involved in both anti-and pro-tumorigenic immune …

Background KMT2A-rearranged acute lymphoblastic leukemia (ALL) in infants is an
aggressive disease with 3-year event-free survival below 40%. Most relapses occur during …

Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each
year more successful therapies are implemented. However, in a subset of cases the overall …

Simple Summary Integrins play key roles in mediating cell adhesion and delivering chemical
and mechanical signals to the interior of the cell. Consequently, they actively control cellular …

CD19-targeted chimeric antigen receptor (CAR) T cell therapy has demonstrated striking
responses among B cell acute lymphoblastic leukemia (B-ALL), but analyses of potential …

The central nervous system (CNS) is the most important site of extramedullary disease in
adults with acute lymphoblastic leukemia (ALL). Although CNS disease is identified only in a …

Hematological cancers such as leukemia, lymphoma, and multiple myeloma have
traditionally been treated with chemo and radiotherapy approaches. Introduction of …

Opinion statement Improvements in systemic therapy in the treatment of acute lymphoblastic
leukemia (ALL) and acute myeloid leukemia (AML) have improved patient outcomes and …

Central nervous system (CNS) involvement remains a challenge in the diagnosis and
treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also …

The coding regions account for only a small part of the human genome, and the remaining
vast majority of the regions generate large amounts of non-coding RNAs. Although non …