Oxygen is vital for life as it is required for many different enzymatic reactions involved in
intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption …

Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but
have also a key role as signaling molecules and in the modulation of epithelial cell …

Background & Aims Besides their physiological role in bile formation and fat digestion, bile
acids (BAs) synthesised from cholesterol in hepatocytes act as signalling molecules that …

Alterations in metabolic pathways are a hallmark of cancer. A deeper understanding of the
contribution of different metabolites to carcinogenesis is thus vitally important to elucidate …

Simple Summary Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis.
The increasing incidence rate of HCC in developed countries has been linked to increasing …

Cancer patients often experience impairments in cognitive function. However, the evidence
for tumor-mediated neurological impairment and detailed mechanisms are still lacking. Gut …

Abstract Context Bile acids (BAs) are pivotal signaling molecules that regulate energy
metabolism and inflammation. Recent epidemiological studies have reported specific …

Purpose Deoxycholic acid (DCA), a secondary bile acid, is reportedly increased in the
serum of patients with nonalcoholic steatohepatitis and animals with experimentally induced …

Cholesterol is a crucial component of membrane bilayers that determines their physical and
functional properties. Cells largely satisfy their need for cholesterol through the novo …

Bile acids (BAs) are the major components of bile and products of cholesterol metabolism.
Cholesterol is catalyzed by a variety of enzymes in the liver to form primary BAs, which are …