Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular
barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During …

Clinical and pathophysiological understanding of septic shock has progressed exponentially
in the previous decades, translating into a steady decrease in septic shock-related morbidity …

The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …

Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …

The anatomy and physiology of the microcirculation in human skin are complex. Normal
cutaneous microcirculation is organized in two parallel plexuses with capillary loops …

Background The endothelial glycocalyx (eGC) covers the luminal surface of the vascular
endothelium and plays an important protective role in systemic inflammatory states and …

Cardiogenic shock is usually defined as primary cardiac dysfunction with low cardiac output
leading to critical organ hypoperfusion, and tissue hypoxia, resulting in high mortality rate …

Background The availability of handheld, noninvasive sublingual video-microscopes allows
for visualization of the microcirculation in critically ill patients. Recent studies demonstrate …

The endothelium is recognized to play an important role in various physiological functions
including vascular tone, permeability, anticoagulation, and angiogenesis. Endothelial …