Importance Widely available and affordable options for the outpatient management of
COVID-19 are needed, particularly for therapies that prevent hospitalization. Objective To …

Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …

Background Insufficient or excessive respiratory effort during acute hypoxemic respiratory
failure (AHRF) increases the risk of lung and diaphragm injury. We sought to establish …

Importance It is unclear whether administration of calcium has a beneficial effect in patients
with cardiac arrest. Objective To determine whether administration of calcium during out-of …

Background Randomized controlled trials (RCT) established the mortality reduction by
tocilizumab (Actemra), baricitinib (Olumiant), and sarilumab (Kevzara) in hospitalized COVID …

Background Atopic dermatitis is a prevalent condition in children and can be effectively
managed with medications such as topical calcineurin inhibitors (pimecrolimus or …

Rationale: The effects of balanced crystalloid versus saline on clinical outcomes for ICU
patients may be modified by the type of fluid that patients received for initial resuscitation …

Rationale: High circulating galectin-3 is associated with poor outcomes in patients with
coronavirus disease (COVID-19). We hypothesized that GB0139, a potent inhaled …

Background Randomized trials are generally performed from a frequentist perspective,
which can conflate absence of evidence with evidence of absence. The RECOVERY trial …

Background The effect of balanced crystalloids compared with that of saline in critically ill
patients overall and in specific subgroups is unclear. We aimed to assess whether use of …