First synthesis for bis-spirothiazolidine derivatives as a novel heterocyclic framework and their biological activity
EM Flefel, WI El-Sofany, HM Awad… - Mini Reviews in …, 2020 - ingentaconnect.com
Background: Spirothiazolidines are versatile synthetic scaffold possessing wide spectrum of
biological interests involving potential anticancer activity. Objective: To report the first …
biological interests involving potential anticancer activity. Objective: To report the first …
A review on the chemistry of nicotinonitriles and their applications
AH Shamroukh, ER Kotb, MM Anwar… - Egyptian Journal of …, 2021 - journals.ekb.eg
Several studies on nicotinonitrile and their derivatives because of their wide range of
therapeutic activities have been reported. Many drugs containing nicotinonitrile derivatives …
therapeutic activities have been reported. Many drugs containing nicotinonitrile derivatives …
Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants
Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and
evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities …
evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities …
Spectroscopic characterization, DFT modeling and antimicrobial studies of some novel nanoparticles mixed ligand complexes of NS bidentate ligand in presence of 2 …
HM Kamal, HA El-Sayed, SA Sadeek… - Journal of Molecular …, 2023 - Elsevier
Abstract Cr (III), Fe (III), Co (II), Ni (II), Cu (II), and Zn (II) interacted with 1-[4-(4-
methoxyphenyl)-6-methyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidin-5-yl] ethanone (L) to form …
methoxyphenyl)-6-methyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidin-5-yl] ethanone (L) to form …
Novel triazolothiadiazole and triazolothiadiazine derivatives containing pyridine moiety: design, synthesis, bactericidal and fungicidal activities
RM Abdelhameed, HA El-Sayed… - Current Bioactive …, 2018 - ingentaconnect.com
Background: One of the important chemical agents in designing of anti-convulsant,
antiatherosclerotic and anti-cancer drugs are pyridine derivatives. Alkyl and aryl derivatives …
antiatherosclerotic and anti-cancer drugs are pyridine derivatives. Alkyl and aryl derivatives …
Synthesis, in vitro, and in silico studies of novel poly‐heterocyclic compounds bearing pyridine and furan moieties as potential anticancer agents
Thirteen novel poly‐heterocyclic compounds containing pyridine and furan moieties were
synthesized and fully characterized by 1 H NMR, 13 C NMR, FTIR, and elemental analysis …
synthesized and fully characterized by 1 H NMR, 13 C NMR, FTIR, and elemental analysis …
[HTML][HTML] Synthesis, molecular docking and in vitro screening of some newly synthesized triazolopyridine, pyridotriazine and pyridine–pyrazole hybrid derivatives
A series of novel pyridine and fused pyridine derivatives have been prepared starting from 6-
(3, 4-dimethylphenyl)-2-hydrazinyl-4-(thiophen-2-yl)-pyridine-3-carbonitrile 1 which on …
(3, 4-dimethylphenyl)-2-hydrazinyl-4-(thiophen-2-yl)-pyridine-3-carbonitrile 1 which on …
Second‐Generation CD73 Inhibitors Based on a 4, 6‐Biaryl‐2‐thiopyridine Scaffold
R Ghoteimi, A Braka, C Rodriguez… - …, 2023 - Wiley Online Library
Abstract Various series of 4, 6‐biaryl‐2‐thiopyridine derivatives were synthesized and
evaluated as potential ecto‐5′‐nucleotidase (CD73) inhibitors. Two synthetic routes were …
evaluated as potential ecto‐5′‐nucleotidase (CD73) inhibitors. Two synthetic routes were …
[HTML][HTML] Development of a novel series of anticancer and antidiabetic: Spirothiazolidines analogs
EM Flefel, WI El-Sofany, RAK Al-Harbi, M El-Shahat - Molecules, 2019 - mdpi.com
4-(4-Aminophenyl)-1-thia-4-azaspiro [4.5] decan-3-one 1 was prepared and allowed to react
with nitrogen nucleophiles to give the corresponding hydrazones 2–4. Further, compound 1 …
with nitrogen nucleophiles to give the corresponding hydrazones 2–4. Further, compound 1 …
[HTML][HTML] Integrated structural, functional, and ADMET analysis of 2-methoxy-4, 6-diphenylnicotinonitrile: the convergence of X-ray diffraction, molecular docking …
AH Bakheit, HM Alkahtani - Molecules, 2023 - mdpi.com
This study systematically investigates the molecular structure and electronic properties of 2-
methoxy-4, 6-diphenylnicotinonitrile, employing X-ray diffraction (XRD) and sophisticated …
methoxy-4, 6-diphenylnicotinonitrile, employing X-ray diffraction (XRD) and sophisticated …