First synthesis for bis-spirothiazolidine derivatives as a novel heterocyclic framework and their biological activity

EM Flefel, WI El-Sofany, HM Awad… - Mini Reviews in …, 2020 - ingentaconnect.com
Background: Spirothiazolidines are versatile synthetic scaffold possessing wide spectrum of
biological interests involving potential anticancer activity. Objective: To report the first …

A review on the chemistry of nicotinonitriles and their applications

AH Shamroukh, ER Kotb, MM Anwar… - Egyptian Journal of …, 2021 - journals.ekb.eg
Several studies on nicotinonitrile and their derivatives because of their wide range of
therapeutic activities have been reported. Many drugs containing nicotinonitrile derivatives …

Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants

F Saleem, KM Khan, N Ullah, M Özil… - Archiv der …, 2023 - Wiley Online Library
Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and
evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities …

Spectroscopic characterization, DFT modeling and antimicrobial studies of some novel nanoparticles mixed ligand complexes of NS bidentate ligand in presence of 2 …

HM Kamal, HA El-Sayed, SA Sadeek… - Journal of Molecular …, 2023 - Elsevier
Abstract Cr (III), Fe (III), Co (II), Ni (II), Cu (II), and Zn (II) interacted with 1-[4-(4-
methoxyphenyl)-6-methyl-2-thioxo-1, 2, 3, 4-tetrahydropyrimidin-5-yl] ethanone (L) to form …

Novel triazolothiadiazole and triazolothiadiazine derivatives containing pyridine moiety: design, synthesis, bactericidal and fungicidal activities

RM Abdelhameed, HA El-Sayed… - Current Bioactive …, 2018 - ingentaconnect.com
Background: One of the important chemical agents in designing of anti-convulsant,
antiatherosclerotic and anti-cancer drugs are pyridine derivatives. Alkyl and aryl derivatives …

Synthesis, in vitro, and in silico studies of novel poly‐heterocyclic compounds bearing pyridine and furan moieties as potential anticancer agents

I Kadi, G Şekerci, H Boulebd, Z Zebbiche… - Journal of Molecular …, 2023 - Elsevier
Thirteen novel poly‐heterocyclic compounds containing pyridine and furan moieties were
synthesized and fully characterized by 1 H NMR, 13 C NMR, FTIR, and elemental analysis …

[HTML][HTML] Synthesis, molecular docking and in vitro screening of some newly synthesized triazolopyridine, pyridotriazine and pyridine–pyrazole hybrid derivatives

EM Flefel, WI El-Sofany, M El-Shahat, A Naqvi… - Molecules, 2018 - mdpi.com
A series of novel pyridine and fused pyridine derivatives have been prepared starting from 6-
(3, 4-dimethylphenyl)-2-hydrazinyl-4-(thiophen-2-yl)-pyridine-3-carbonitrile 1 which on …

Second‐Generation CD73 Inhibitors Based on a 4, 6‐Biaryl‐2‐thiopyridine Scaffold

R Ghoteimi, A Braka, C Rodriguez… - …, 2023 - Wiley Online Library
Abstract Various series of 4, 6‐biaryl‐2‐thiopyridine derivatives were synthesized and
evaluated as potential ecto‐5′‐nucleotidase (CD73) inhibitors. Two synthetic routes were …

[HTML][HTML] Development of a novel series of anticancer and antidiabetic: Spirothiazolidines analogs

EM Flefel, WI El-Sofany, RAK Al-Harbi, M El-Shahat - Molecules, 2019 - mdpi.com
4-(4-Aminophenyl)-1-thia-4-azaspiro [4.5] decan-3-one 1 was prepared and allowed to react
with nitrogen nucleophiles to give the corresponding hydrazones 2–4. Further, compound 1 …

[HTML][HTML] Integrated structural, functional, and ADMET analysis of 2-methoxy-4, 6-diphenylnicotinonitrile: the convergence of X-ray diffraction, molecular docking …

AH Bakheit, HM Alkahtani - Molecules, 2023 - mdpi.com
This study systematically investigates the molecular structure and electronic properties of 2-
methoxy-4, 6-diphenylnicotinonitrile, employing X-ray diffraction (XRD) and sophisticated …