Within the last twenty years the view on reactive oxygen species (ROS) has changed; they
are no longer only considered to be harmful but also necessary for cellular communication …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Giant cell arteritis (GCA) is a granulomatous vasculitis affecting large arteries, especially the
aorta and the extracranial branches of the external carotid artery. Its exact pathogenesis is …

Objective—Reactive oxygen species have been implicated as signaling molecules
modulating the activity of redox-sensitive transcription factors such as nuclear factor kappa B …

The role of inflammation in the pathogenesis of abdominal aortic aneurysms (AAA) is well
established. The inflammatory process leads to protease-mediated degradation of the …

Reactive oxygen species (ROS) have physiological roles as second messengers, but can
also exert detrimental modifications on DNA, proteins and lipids if resulting from enhanced …

Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease
characterised by unregulated proteolytic destruction of lung tissue mediated via a protease …

Background—Human urotensin II (hU-II) is a potent vasoactive peptide possibly involved in
pulmonary hypertension. Because the signaling mechanisms activated by this peptide in the …

Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50
years in Western countries. To shed light onto the genetic background influencing …

Reactive oxygen species (ROS) exert various biological effects and contribute to signaling
events during physiological and pathological processes. Enhanced levels of ROS are highly …