The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

The recovery of an intact epithelium following lung injury is critical for restoration of lung
homeostasis. The initial processes following injury include an acute inflammatory response …

Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Keratinocyte growth factor (KGF) is a paracrine-acting, epithelial mitogen produced by cells
of mesenchymal origin. It is a member of the fibroblast growth factor (FGF) family, and acts …

When mouse embryonic fibroblasts in suspension contact a matrix-coated surface, they
rapidly adhere and spread. Using total internal reflection fluorescence microscopy of dye …

Acute myocardial infarction (MI) triggers oxidative stress, which worsen cardiac function,
eventually leads to remodeling and heart failure. Unfortunately, effective therapeutic …

Irradiation of salivary glands during radiotherapy treatment of patients with head and neck
cancer evokes persistent hyposalivation. This results from depletion of stem cells, which …

Rationale: Increasing epithelial repair and regeneration may hasten resolution of lung injury
in patients with the acute respiratory distress syndrome (ARDS). In animal models of ARDS …

Melanogenesis and melanosome transfer from the melanocytes to the neighboring
keratinocytes are induced by ultraviolet radiation and modulated by autocrine and paracrine …

Keratinocyte growth factor (KGF) is a locally acting epithelial mitogen that is produced by
cells of mesenchymal origin and has an important role in protecting and repairing epithelial …