Angiotensinogen, the precursor molecule for angiotensins I, II and III, and the enzymes
renin, angiotensin-converting enzyme (ACE), and aminopeptidases A and N may all be …

The brain's three sensory circumventricular organs, the subfornical organ, organum
vasculosum of the lamina terminalis and the area postrema lack a blood brain barrier and …

Osmotic homeostasis is one of the most aggressively defended physiological parameters in
vertebrates. However, the molecular mechanisms underlying osmotic regulation are poorly …

Located in the midline anterior wall of the third cerebral ventricle (ie the lamina terminalis),
the median preoptic nucleus (Mn PO) receives a unique set of afferent neural inputs from …

Sodium appetite, the behavioural drive to ingest salt, is stimulated by prolonged
physiological sodium deficiency in many animal species. The same neural mechanisms that …

Evidence indicates that angiotensin II (Ang II) enhances sympathetic nervous system (SNS)
activity centrally and peripherally, but the exact mechanisms of this activation are not well …

We have previously shown that mice transgenic for both the human renin and human
angiotensinogen genes (RA+) exhibit appropriate tissue-and cell-specific expression of both …

Thirst motivates animals to seek fluid and drink it. It is regulated by the central nervous
system and arises from neural and chemical signals from the periphery interacting in the …

One of the most prominent concepts to emerge in cardiovascular research over the past
decade, especially in areas focused on angiotensin II (AngII), is that reactive oxygen species …

Sepsis is defined as a potentially fatal organ dysfunction caused by a dysregulated host
response to infection. Despite tremendous progress in the medical sciences, sepsis remains …