Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Leptin, a hormone that is capable of effectively reducing food intake and body weight, was
initially considered for use in the treatment of obesity. However, obese subjects have since …

Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …