Notch signalling is critically involved in vascular morphogenesis and function. Four Notch
isoforms (Notch1–4) regulating diverse cellular processes have been identified. Of these …

The Notch signaling pathway is conserved among mammalian species and controls
proliferation, differentiation, and cell death in many organs throughout the body including the …

Understanding the dynamics of endogenous protein–protein interactions in complex
networks is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of …

Pulsed electromagnetic fields (PEMFs) have been used to treat bone diseases, particularly
nonunion healing. Although it is known that PEMFs promote the osteogenic differentiation of …

Abstract Rationale: Hepatic stellate cells (HSCs) are liver-specific pericytes regulating
vascular remodeling during hepatic fibrosis. Here, we investigated how ligustrazine affects …

We discovered a small series of hit compounds that show multitargeting activities against
key targets in Alzheimer′ s disease (AD). The compounds were designed by combining the …

Reactive oxygen species (ROS), traditionally viewed as toxic by‐products that cause
damage to biomolecules, now are clearly recognized as key modulators in a variety of …

BACKGROUND AND PURPOSE Hepatic stellate cells (HSCs) are liver‐specific pericytes
regulating angiogenesis during liver fibrosis. We aimed to elucidate the mechanisms by …

Unlike age-matched men, premenopausal women benefit from cardiovascular protection.
Estrogens protect against apoptosis of endothelial cells (ECs), one of the hallmarks of …

Scope We aimed examining apple polyphenols' effect on uricemia and endothelial function
in a sample of overweight subjects. Methods and results This was a two‐phased study. In …